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In the fourth year of prophethood, the following verse from Surah Al-Hijr was revealed:
فَاصْدَعْ بِمَا تُؤْمَرُ وَ أَعْرِضْ عَنِ الْمُشْرِكِينَ ,
Translation: "Therefore, publicly announce what you are commanded, and turn away (your) face from the polytheists." (Verse 94, Al-Hijr).
In this blessed verse, Allah commanded the Beloved Prophet ﷺ to openly preach the religion. Following this divine command, the Beloved Prophet ﷺ began to openly propagate Islam and condemn polytheism. As a result, the entire Quraysh tribe, and indeed all of Arabia, began to oppose him and cause various sorts of troubles to him and to the Muslims.